These mice exhibit severe immunodeficiency because of the absence of T cells and B cells, and are a useful model for studying immunodeficiency caused by HIV infection or radiation exposure. Due to the absence of T and B cells, these mice show severe immunodeficiency and are therefore unlikely to reject transplanted heterologous cells or tissues. The color of these mice is determined by a stereotyped recessive inheritance pattern. Severe combined immunodeficiency (SCID) mice are spontaneous mutants that were first identified in C. In order to determine whether or not patients suffering from immunodeficiency diseases should use self-collected AdMSCs, we collected AdMSCs from severely immunodeficient mice and examined their cell dysfunction. (Introduction line 144-164: revision history) Response to last comment 1 :As suggested, we have now added text about the aim of the work to the Introduction, as follows: The aim of the work must be better emphasized. Major points: -The introduction must be significantly revised. I encourage the resubmission after a strong revision. My opinion is that in the current form the manuscript is not suitable for publication. The issue is very important, however, in this current form the manuscript needs to be strongly improved. Last comment 1: The manuscript by Nakaschima and co-authors describes the differential proteomic analysis in adipose stem cells isolated from C57BL/6 and SCID mice by LC-MS/MS in order to address the immunomodulatory potential of these mesenchymal stem cells. The text of the re-corrected manuscript is shown below. Then, we reworked the manuscript carefully according to the reviewer's advice. Response to current comment 1 :We carefully reviewed the earlier submitted revisions. I suggest the authors revise carefully the manuscript. Unfortunately, the revision track makes difficult to follow the text. In addition, the sentences that were newly added and corrected in this revision are indicated by yellow highlighting.Ĭurrent comment 1: The manuscript by Yoshiki Nakashima and co-authors was improved significantly. The deletions are clearly indicated in the text. In addition, the text has been reworked to reflect previous advice that was received from the reviewers. We clarified the changes in the previously submitted revisions. We thank the reviewers for giving us the opportunity to revise the text a second time. We apologize for the large number of errors in the previously submitted revised manuscript. Title: “Immunodeficiency-associated differences observed in mouse adipose-derived mesenchymal stem cells"Īuthors: Yoshiki Nakashima, Saifun Nahar, Chika Miyagi-Shiohira, Takao Kinjo, Naoya Kobayashi, Shinji Kitamura, Issei Saitoh, Masami Watanabe, Jiro Fujita and Hirofumi Noguchi. Unfortunately, the revision track makes difficult to follow the text. The manuscript by Yoshiki Nakashima and co-authors was improved significantly.
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